Idax proteín

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The protein has a mass of 21 kDa and length of 198 residues. It may be known by other names, including: inhibition of the Dvl and axin complex protein, Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex), CXXC finger 4, and CXXC-type zinc finger protein 4.

IDAX downregulates TET2 protein by activating caspase pathway. Application Notes. Recombinant TET2 (1129-2002) protein is suitable for use in cytosine oxygenase assays, enzyme kinetics, inhibitor screening, and selectivity profiling. TET Activity Assay Conditions: 250 nM of 30bp DNA oligos (sequence: 5' … In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex).

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Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). Anti-CXXC4 (C-terminal) antibody produced in goat affinity isolated antibody, buffered aqueous solution; Synonym: CXXC finger 4, Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex), IDAX, MGC149872, inhibition of the Dvl and Axin complex; find Sigma-Aldrich-SAB2501953 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Idax CRISPR Activation Plasmid (m) consists of three plasmids at a 1:1:1 mass ratio: a plasmid encoding the deactivated Cas9 (dCas9) nuclease (D10A and N863A) fused to the transactivation domain VP64, and a blasticidin resistance gene; a plasmid encoding the MS2-p65-HSF1 fusion protein, and a hygromycin resistance gene; a plasmid encoding a target-specific 20 nt guide RNA fused to two MS2 RNA … IDAX (also known as CXXC4), a reported inhibitor of Wnt signaling, regulates Tet2 protein expression . Unexpectedly, IDAX expression results in caspase activation and Tet2 protein downregulation in a manner that depends on DNA binding through the IDAX CXXC domain, suggesting that IDAX recruits Tet2 to DNA before degradation .

K03344 IDAX; Dvl-binding protein IDAX 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03000 Transcription factors K03344 IDAX; Dvl-binding protein IDAX Transcription factors [BR:ko03000] Eukaryotic type Zinc finger CXXC CpG-binding proteins K03344 IDAX; Dvl-binding protein IDAX. BRITE hierarchy: Genes: HSA: 80319(CXXC4) PTR: 471261(CXXC4) PPS: …

PubMed Article Plasmids from Article. ID Plasmid Purpose ; 49446: FH-TET3-pEF: This plasmid … 01/05/2013 Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex) 1 2: Inhibition Of The Dvl And Axin Complex Protein 2 3: CXXC Finger 4 2: CXXC-Type Zinc Finger Protein 4 2: External Ids: HGNC: 24593 1 : Entrez Gene: 80319 2 : Ensembl: ENSG00000168772 7 : OMIM: 611645 5 : UniProtKB: Q9H2H0 3 : Export aliases for CXXC4 gene to outside databases. Previous GC identifiers: GC04M105853 GC04M105747 … This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway.

Idax proteín

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Idax proteín

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Anti-Idax antibodies can be readily obtained from commercial sources. The Idax protein is a reported synonym for the human gene CXXC4, encoding CXXC finger protein 4.

… 1: Idax protein, Xenopus [Supplementary Concept] an inhibitor of the canonical Wnt pathway required for anterior neural structure formation; GenBank AB085700 Date introduced: December 20, 2004 Heading Mapped to: Carrier Proteins Xenopus Proteins Entry Terms: XIdax protein, Xenopus inhibition of the Dvl and Axin complex protein, Xenopus Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Journal: Nature Publication Year: 2013 Authors: Myunggon Ko,Jungeun An,Hozefa S Bandukwala,Lukas Chavez,Tarmo Aijo,William A Pastor,Matthew F Segal,Huiming Li,Kian Peng Koh,Harri Lahdesmaki,Patrick G Hogan,L Aravind,Anjana Rao PubMed link: 23563267 Funding Grants: Generation of regulatory T … The CXXC domains of TET2 (encoded by the distinct gene IDAX) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent Anti-Idax antibodies can be readily obtained from commercial sources. The Idax protein is a reported synonym for the human gene CXXC4, encoding CXXC finger protein 4. The full-length protein is 198 amino acids in length and 20978 daltons in mass. Visit the antibody supplier page for key details, including validated applications and target specificity. Anti-Idax Antibody Products.

The cysteine-rich protein Idax acts as a negative regulator of Wnt signaling in mammals by interaction with Dvl in the region of the PDZ domain. In an effort to clarify the st … Dishevelled (Dvl) is the essential signal transduction component of both canonical and non-canonical Wnt signaling pathways. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Anti-Idax antibodies can be readily obtained from commercial sources. The Idax protein is a reported synonym for the human gene CXXC4, encoding CXXC finger protein 4.

Journal: Nature Publication Year: 2013 Authors: Myunggon Ko,Jungeun An,Hozefa S Bandukwala,Lukas Chavez,Tarmo Aijo,William A Pastor,Matthew F Segal,Huiming Li,Kian Peng Koh,Harri Lahdesmaki,Patrick G Hogan,L Aravind,Anjana Rao PubMed link: 23563267 Funding Grants: Generation of regulatory T … The CXXC domains of TET2 (encoded by the distinct gene IDAX) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent Anti-Idax antibodies can be readily obtained from commercial sources. The Idax protein is a reported synonym for the human gene CXXC4, encoding CXXC finger protein 4. The full-length protein is 198 amino acids in length and 20978 daltons in mass. Visit the antibody supplier page for key details, including validated applications and target specificity. Anti-Idax Antibody Products.

Idax proteín

Dry Ice. 外观. Recombinant TET2 (1129-2002) protein is supplied at a concentration  CXXC Finger Protein 4 (CXXC4) (C-Term) 抗体(PE) Primary Antibody Protein 4 , CXXC4, Inhibition of the Dvl and Axin Complex Protein, IDAX, MGC149872)  ALTERNATE NAMES: CXXC4 Antibody: IDAX, IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein. ACCESSION NO. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. M Ko, J An, HS Bandukwala, L Chavez, T Äijö, WA Pastor,   The dishevelled gene encodes a much-studied signal transduction protein that Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

Visit the antibody supplier page for key details, including validated applications and target Protein expression was chemically induced by the addition of isopropyl-1-thio-β-d-galactoside (IPTG) to a final concentration of 1 mM and the cells were harvested 6 h later by centrifugation. Production of unlabeled rat Idax. The Idax construct used was the C-terminal half of the protein running from residue 109 to the C-terminus.

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K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27] K04507 CACYBP, SIP; calcyclin binding protein K04508 TBL1; transducin (beta)-like 1 K04510 VANGL; vang-like K04511 PRICKLE; prickle K04512 DAAM; dishevelled associated activator of morphogenesis K04513 RHOA; Ras homolog gene family, member A K04515 CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II …

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PMID: 11113207) Hino S … Kikuchi A (Molecular and cellular biology 2001) 2 3 4 23; DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for  Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. 2013 May 2;497(7447):122-6.

whereas TET2 pairs up with IDAX protein (or CXXC4), an independent CXXC domain-containing protein that was originally encoded bythe TET2 gene andseparated from thecatalytic domainof TET2 through chromosomal inversion during evolution (Ko et al., 2013). The CXXC domain is highly conserved and responsible for associating with unmethylated CpG -containing sequences (Ko et al., 2013; Zhang et …

In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for  Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. 2013 May 2;497(7447):122-6. doi:  CXXC Finger Protein 4; IDAX; Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex); Inhibition Of The Dvl And Axin Complex Protein; CXXC-Type   Since this Dvl-interacting protein is a novel protein, we designated it Idax (for inhibition of the Dvl and Axin complex). The mRNA of Idaxwas highly expressed in  CXXC-type zinc finger protein 4. Gene -Experimental evidence at protein leveli. This indicates the type of evidence that Synonyms:IDAX.

Epub 2013 Apr 7. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PMID: 11113207) Hino S … Kikuchi A (Molecular and cellular biology 2001) 2 3 4 23; DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for  Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. 2013 May 2;497(7447):122-6.